Well, LSU could do what Illinois did -
Have the DBs play 8 - 10 yards off the WR, and hope
OSU (as they did not against Ill) never adjusts to the free 5 yards they're allowing, in hopes of hitting the deep ball.
As for stopping
OSU's run, I don't think that's possible. Contain it, but not stop it would be the hope. My guess is because LSU's relative strength on the Dline comes inside,
OSU will try to hit plays off tackle, so I'd say LSU's LBs will have to do well covering the edges.